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In vivo and in vitro models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expression of genes related to glutathione anabolic metabolism (GCLC, GCLM, and SLC7A11) was significantly down-regulated

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Moreover, increasing the dose of the ACTL6A HR-deleted mutant failed to reverse the reduction in GCLC mRNA expression caused by knocking down ACTL6A expression (Fig

Xue, Y., Liu, S., Guo, J., Meng, T., Zhang, X., Li, H., & Guo, X